オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Gabapentin Acts within the Locus Coeruleus to Alleviate Neuropathic Pain
掲載誌名	正式名：ANESTHESIOLOGY ISSNコード：00033022
出版社	LIPPINCOTT WILLIAMS&WILKINS
巻・号・頁	109(6),1077-1084頁
著者・共著者	Ken-ichiro Hayashida,Hideaki Obata,Kunie Nakajima,James C. Eisenach
発行年月	2008/12
概要	Background: Gabapentin recruits descending inhibition to produce analgesia after nerve injury, but whether this is a local action in the brainstem is unknown. The authors hypothesized that gabapentin activates noradrenergic neurons in the locus coeruleus (LC) by a local action.Methods: Male. rats underwent L5-L6 spinal nerve ligation (SNL) and received drugs by intra-LC or systemic routes for behavior testing, immunohistochemistry in die LC, and microdialysis in the spinal dorsal horn. In other studies, brainstem slices from normal and SNL animals were used for immunohistochemistry.Results: SNL increased phosphorylated cyclic adenosine monophosphate response element binding protein (I)CREB)expressing nuclei bilaterally in the LC, and increased noradrenaline release in the spinal dorsal horn. Gabapentin, whether in isolated brainstem slices or in conscious or anesthetized animals, increased pCREB-expressing nuclei in the LC The net increase in pCREB expression by gabapentin did notdiffer between normal and SNL conditions. This gabapentin-induced pCREB activation in LC neurons was abolished by an AMPA receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Intra-LC-injec
DOI	10.1097/ALN.0b013e31818dac9c
PMID	19034104