オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Autologous bone marrow transplantation and hyperbaric oxygen therapy for patients with thromboangiitis obliterans
掲載誌名	正式名：Angiology ISSNコード：00033197
巻・号・頁	58(4),429-434頁
著者・共著者	Shigeru Saito,Koichi Nishikawa,Hideaki Obata,Fumio Goto
発行年月	2007/08
概要	Many patients suffering from severe ischemic limb disease inevitably experience amputation, despite intensive therapies. Sympathectomy and hyperbaric oxygen therapy are optional therapies for patients with peripheral circulation disorders. Recently, several clinical studies have established that implantation of bone marrow-mononuclear cells into ischemic limbs increases collateral vessel formation. In the present study, autologous implantation of bone marrow-mononuclear cells was prescribed to 7 patients with ischemic limbs because of peripheral arterial disease. Although the extent of the improvement was not consistent among the 7 cases, all of the patients experienced some improvement in their symptoms. Transcutaneous oxygen partial pressure measured in a hyperbaric chamber increased in 5 patients. No side effects were observed. In conclusion, combined use of autologous bone marrow transplantation and hyperbaric oxygen therapy may be safe and effective for achievement of therapeutic angiogenesis. ©2007 Sage Publications.
DOI	10.1177/0003319706292015
PMID	17652224