オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury
掲載誌名	正式名：EUROPEAN JOURNAL OF PHARMACOLOGY ISSNコード：00142999
出版社	ELSEVIER SCIENCE BV
巻・号・頁	567(1-2),89-94頁
著者・共著者	Hideaki Obata,Naomi Ito,Masayuki Sasaki,Shigeru Saito,Fumio Goto
発行年月	2007/07
概要	Intrathecal administration of serotonin type 2C (5-HT2C) receptor agonists produces an antiallodynic effect in a rat model of neuropathic pain. In the present study, we characterized this effect pharmacologically. Allodynia was produced by tight ligation of the fifth (L5) and sixth (L6) lumbar spinal nerves on the left side, and was measured by applying von Frey filaments to the left hindpaw. 6-chloro-2-(1-piperazinyl)-pyrazine (MK212; 100 mu g) and 1-(m-chlorophenyl)-piperazine (mCPP; 300 mu g) were used as 5-HT2C receptor agonists. Intrathecal administration of these agonists resulted in an antiallodynic effect. Intrathecal administration of atropine (30 mu g), a muscarinic receptor antagonist, and yohimbine (30 mu g), an alpha(2)-adrenoceptor antagonist, reversed the effects of 5-HT2C receptor agonists. Intrathecal pretreatment with 6-hydroxydopamine, an adrenergic neurotoxin, inhibited the antiallodynic effect of MK212. These results suggest that spinal noradrenergic mechanisms are involved in the antiallodynic effects of intrathecally administered 5-HT2C receptor agonists. Previously, we demonstrated that intrathecal administration of 5-HT2A receptor agonists also produced ant
DOI	10.1016/j.ejphar.2007.03.029
PMID	17451674