オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Landiolol and esmolol prevent tachycardia without altering cerebral blood flow
掲載誌名	正式名：CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE ISSNコード：0832610X
出版社	CANADIAN ANESTHESIOLOGISTS SOC
巻・号・頁	52(10),1027-1034頁
著者・共著者	S Saito,F Nishihara,T Akihiro,K Nishikawa,H Obata,F Goto,N Yuki
発行年月	2005/12
概要	Purpose: Several beta-adrenergic-blocking drugs have been used during electroconvulsive therapy (ECT) to stabilize the hemodynamic alterations following electrical stimulation. The effects of two ultra-short acting beta-adrenergic-blocking drugs, esmolol and landiolol, on systemic and cerebral circulation were studied during ECT.Methods: In the first study (n=15), dose-dependent hemodynamic changes were studied when landiolol was administered immediately after induction of anesthesia. In the second study (n=12), effects of esmolol and landiolol on systemic and cerebral circulation were compared. Patients in Study 1 received three doses of landiolol, and patients in Study 2 received two types of beta-adrenergic-blocking drugs, in a randomized crossover design in a series of ECT trials.Results: In the first study, 0.25 to 0.5 mg.kg(-1) landiolol induced a lower heart rate after the electrical stimulation compared to vehicle (P<0.01). Landiolol did not have significant effects on blood pressure. In the second study, heart rate was stabilized by 1.0 mg.kg(-1) esmolol iv or 0.5 mg.kg(-1) landiolol iv. Increase in mean blood pressure was ameliorated by esmolol (P<0.01), but not b
PMID	16326671