|
オバタ ヒデアキ
OBATA Hideaki
小幡 英章 所属 埼玉医科大学 医学部 総合医療センター 麻酔科（麻酔科、産科麻酔科） 職種 教授 |
|
| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Systemic ketamine inhibits hypersensitivity after surgery via descending inhibitory pathways in rats |
| 掲載誌名 | 正式名：CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE ISSNコード：0832610X |
| 出版社 | CANADIAN ANESTHESIOLOGISTS SOC |
| 巻・号・頁 | 52(5),498-505頁 |
| 著者・共著者 | S Koizuka,H Obata,M Sasaki,S Saito,F Goto |
| 発行年月 | 2005/05 |
| 概要 | Purpose: Systemic ketamine suppresses several types of chronic pain. Although ketamine is used as a general anesthetic agent, the analgesic effect of systemic ketamine for early-stage postoperative pain is not clear. We investigated the efficacy and mechanism of systemic ketamine in a rat model of postoperative pain,Methods: An incision was made in the plantar aspect of the left hind paw in male Wistar rats. Mechanical hypersensitivity was measured using calibrated von Frey filaments. The anti-hypersensitivity effect of systemic or intrathecal administration of ketamine was determined every hour after making the incision. We examined the effects of intrathecal pretreatment with yohimbine, an alpha(2)-adrenoceptor antagonist, and methysergide, a serotonergic receptor antagonist, on the anti-hypersensitivity effect of ketamine. We also examined the effect of systemic ketamine on the c-fos immunoreactivity in the spinal cord.Results: Systemic administration of ketamine at doses from 3 to 30 mg(.)kg(-1) produced anti-hypersensitivity effects in a dose-dependent manner. Intrathecal administration of ketamine had no effect. There was no significant difference between effects of pre- an |
| PMID | 15872129 |