オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Antiallodynic effects of intrathecally administered 5-HT2C receptor agonists in rats with nerve injury
掲載誌名	正式名：PAIN ISSNコード：03043959
出版社	ELSEVIER SCIENCE BV
巻・号・頁	108(1-2),163-169頁
著者・共著者	H Obata,S Saito,S Sakurazawa,M Sasaki,T Usui,F Goto
発行年月	2004/03
概要	Intrathecal administration of serotonin type 2 (5-HT2) receptor agonists, alpha-methyl-5-hydroxytryptamine maleate (alpha-m-5-HT) or (+/-)-1-(4-iodo-2,5-dimethoxyphenyt)-2-aminopropane hydrochloride (DOI), produces antiallodynic effects in a rat model of neuropathic pain. In the present study, we examined the antiallodynic effects of intrathecally administered agents which are selective for 5-HT2C receptors. Allodynia was produced by tight ligation of the left L5 and L6 spinal nerves, and was measured by applying von Frey filaments to the left hindpaw. Administration of the 5-HT2C receptor agonist, 6-chloro-2-(1-piperazinyl)-pyrazine (MK212; 3-100 mug), 1-(m-chlorophenyl)-piperazine (mCPP; 30-300 mug), or 1-(in-trifluoromethylphenyl)-piperazine (TFMPP; 30-300 jig), produced antiallodynic effects in a dose-dependent manner with no associated motor weakness. The ED50 values of MK212, mCPP, and TFMPP were 39.2, 119.9, and 191.9 mug, respectively. Intrathecal pretreatment with the selective 5-HT2C receptor antagonist RS-102221 (30 mug) diminished the effects of the highest doses of 5-HT2C receptor agonists. The preferential 5-HT2A receptor antagonist ketanserin (30 mug) did not reverse
DOI	10.1016/j.pain.2003.12.019
PMID	15109520