オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Oral etodolac, a COX-2 inhibitor, reduces postoperative pain immediately after fast-track cardiac surgery
掲載誌名	正式名：Journal of Anesthesia ISSNコード：09138668
巻・号・頁	18(1),9-13頁
著者・共著者	Shiro Koizuka,Shigeru Saito,Hideaki Obata,Masayuki Sasaki,Koichi Nishikawa,Kenichiro Takahashi,Yuji Saito,Fumio Goto
発行年月	2004
概要	Purpose. The present study was designed to evaluate the efficacy of a cyclooxygenase (COX)-2 inhibitor, etodolac, on postoperative pain after fast-track cardiac surgery, and to examine the changes in plasma etodolac concentration after oral administration. Methods. Thirty patients scheduled for elective coronary artery bypass grafting (CABG) surgery were randomly assigned preoperatively in a double-blind fashion to receive either vehicle (n = 15) or etodolac 400mg (n = 15) via a gastric tube at the end of the surgery. Standardized fast-track cardiac anesthesia was used. In both groups, postoperative pain was treated with buprenorphine suppository. Visual analogue pain scores (VASs) were recorded immediately after extubation and at 24h after surgery. Plasma etodolac concentration was measured at 1, 2, and 6 h after administration (n = 8). Results. No difference was detected in time to extubation between the etodolac group (209 ± 85 min, mean ± SD) and the vehicle group (207 ± 98 min). VASs were significantly lower in the etodolac (2.3 ± 2.1) vs the vehicle group (5.8 ± 2.0) immediately after extubation (P = 0.009), but no difference was detected in pain scores at 24 h after sur
DOI	10.1007/s00540-003-0215-3
PMID	14991469