オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	A rat model of postthoracotomy pain: Behavioural and spinal cord NK-1 receptor assessment
掲載誌名	正式名：Canadian Journal of Anesthesia ISSNコード：0832610X
出版社	Canadian Anaesthetists' Society
巻・号・頁	48(7),665-676頁
著者・共著者	T. Nara,S. Saito,H. Obata,F. Goto
発行年月	2001
概要	Purpose: To develop a new rat model of postthoracotomy pain for investigating its mechanisms and clarifying neurochemical changes. Methods: Male Wistar rats were randomly assigned to three groups that underwent either fourth and fifth intercostal nerve ligation, cutting of the fourth and fifth ribs, or a sham operation in which only pleura was cut. For behavioural response assessment during the following month, pinch and touch were used as mechanical stimuli, and acetone was used as a cold thermal stimulus. In addition, 125I-substance P autoradiography was used to determine neurokinin (NK) receptor density in spinal cord laminae I and II at one to six weeks after surgery. Results: In rats with nerve ligation, hypersensitivity to noxious and non-noxious stimuli continued throughout the month. The"mirror phenomenon"was observed. The lowest threshold was obtained in the dorsomedial portion of the T4 dermatome on the side of surgery. In rats with rib cutting, a lowered threshold to noxious and non-noxious stimuli was observed for two weeks. In rats with sham operations, hypersensitivity was seen only at postoperative day one. NK-I receptor density on the side of operation increased s
DOI	10.1007/BF03016201
PMID	11495874