オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Antinociception in rat by sarpogrelate, a selective 5-HT2A receptor antagonist, is peripheral
掲載誌名	正式名：EUROPEAN JOURNAL OF PHARMACOLOGY ISSNコード：00142999
出版社	ELSEVIER SCIENCE BV
巻・号・頁	404(1-2),95-102頁
著者・共著者	H Obata,S Saito,K Ishizaki,F Goto
発行年月	2000/09
概要	The antinociceptive effect of sarpogrelate, a new selective 5-hydroxytriptamine (5-HT)(2A) receptor antagonist, in the formalin test was examined in rats. Sarpogrelate was administered intraperitoneally, locally (subcutaneously at the formalin test sire) or intrathecally 10 min before formalin injection. Intraperitoneal (1-100 mg/kg) and local (0.01-1 mg) administration of sarpogrelate suppressed flinching behavior in both phases 1 (0-9 min) and 2 (10-60 min) in a dose-dependent manner. Intraperitoneal(100 mg/kg) andlocal(1 mg) injection 7 min after formalin injection reduced phase 2 flinches to the same degree as with the pre-treatment. Intrathecal administration (1-100 mu g) showed no antinociceptive action, and facilitated phase 2 flinches at 10 mu g. The plasma concentration of sarpogrelate after local administration of 1 mg was lower than after intraperitoneal administration of 10 mg/kg, although local administration produced more potent antinociception. The data imply that the antinociceptive effect of sarpogrelate results mainly from an action at peripheral sites. (C) 2000 Elsevier Science B.V. All rights reserved.
PMID	10980267