オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The effect of intrathecal magnesium sulphate on nociception in rat acute pain models
掲載誌名	正式名：ANAESTHESIA ISSNコード：00032409
出版社	BLACKWELL SCIENCE LTD
巻・号・頁	54(3),241-246頁
著者・共著者	K Ishizaki,M Sasaki,S Karasawa,H Obata,T Nara,F Goto
発行年月	1999/03
概要	We examined the antinociceptive effect of intrathecally administered magnesium sulphate (MgSO4) in rats, using acute pain models including mechanical pressure, heat and subcutaneous formalin injection. According to the locomotion test 10 mu l of 6.2% MgSO4 did not produce motor paralysis. At the same dose, responses to pressure and heat were intact, compared with controls given saline. MgSO4 produced depression of pain responses only after the first 10 min in the formalin test. Our studies indicated that MgSO4 did not show remarkable antinociceptive effects in acute pain models.
PMID	10364859