イワサキ　ユキコ   IWASAKI Yukiko   岩崎　由希子    所属   埼玉医科大学  医学部 緩和医療科    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Lnk prevents inflammatory CD8⁺ T-cell proliferation and contributes to intestinal homeostasis.
掲載誌名	正式名：European journal of immunology
巻・号・頁	44(6),1622-32頁
著者・共著者	Hiroko Katayama,Taizo Mori,Yoichi Seki,Masaki Anraku,Masanori Iseki,Masashi Ikutani,Yukiko Iwasaki,Nobuaki Yoshida,Kiyoshi Takatsu,Satoshi Takaki
発行年月	2014/06
概要	The intracellular adaptor Lnk (also known as SH2B3) regulates cytokine signals that control lymphohematopoiesis, and Lnk(-/-) mice have expanded B-cell, megakaryocyte, and hematopoietic stem-cell populations. Moreover, mutations in the LNK gene are found in patients with myeloproliferative disease, whereas LNK polymorphisms have recently been associated with inflammatory and autoimmune diseases, including celiac disease. Here, we describe a previously unrecognized function of Lnk in the control of inflammatory CD8(+) T-cell proliferation and in intestinal homeostasis. Mature T cells from newly generated Lnk-Venus reporter mice had low but substantial expression of Lnk, whereas Lnk expression was downregulated during homeostatic T-cell proliferation under lymphopenic conditions. The numbers of CD44(hi) IFN-γ(+) CD8(+) effector or memory T cells were found to be increased in Lnk(-/-) mice, which also exhibited shortening of villi in the small intestine. Lnk(-/-) CD8(+) T cells survived longer in response to stimulation with IL-15 and proliferated even in nonlymphopenic hosts. Transfer of Lnk(-/-) CD8(+) T cells together with WT CD4(+) T cells into Rag2-deficient mice recapitulated a
DOI	10.1002/eji.201343883
PMID	24536025