イワサキ　ユキコ   IWASAKI Yukiko   岩崎　由希子    所属   埼玉医科大学  医学部 緩和医療科    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ-producing T cells.
掲載誌名	正式名：Journal of immunology (Baltimore, Md. : 1950)
巻・号・頁	193(4),1728-36頁
著者・共著者	Taizo Mori,Yukiko Iwasaki,Yoichi Seki,Masanori Iseki,Hiroko Katayama,Kazuhiko Yamamoto,Kiyoshi Takatsu,SatoshiTakaki
発行年月	2014/08
概要	Dendritic cells (DCs) are proficient APCs that play crucial roles in the immune responses to various Ags and pathogens and polarize Th cell immune responses. Lnk/SH2B adaptor protein 3 (Sh2b3) is an intracellular adaptor protein that regulates B lymphopoiesis, megakaryopoiesis, and expansion of hematopoietic stem cells by constraining cytokine signals. Recent genome-wide association studies have revealed a link between polymorphism in this adaptor protein and autoimmune diseases, including type 1 diabetes and celiac disease. We found that Lnk/Sh2b3 was also expressed in DCs and investigated its role in the production and function of DC lineage cells. In Lnk(-/-) mice, DC numbers were increased in the spleen and lymph nodes, and growth responses of bone marrow-derived DCs to GM-CSF were augmented. Mature DCs from Lnk(-/-) mice were hypersensitive and showed enhanced responses to IL-15 and GM-CSF. Compared to normal DCs, Lnk(-/-) DCs had enhanced abilities to support the differentiation of IFN-γ-producing Th1 cells from naive CD4(+) T cells. This was due to their elevated expression of IL-12Rβ1 and increased production of IFN-γ. Lnk(-/-) DCs supported the appearance of IFN-γ-prod
DOI	10.4049/jimmunol.1303243
PMID	25024389