コレマツ　セイゴ   KOREMATSU Seigo   是松　聖悟    所属   埼玉医科大学  医学部 総合医療センター　小児科（小児科､総合周産期母子医療センター新生児科、小児救命救急センター）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Elevated serum anti-phosphatidylcholine IgG antibodies in patients with influenza vaccination-associated optic neuritis
掲載誌名	正式名：VACCINE ISSNコード：0264410X
出版社	ELSEVIER SCI LTD
巻・号・頁	32(48),6345-6348頁
著者・共著者	Seigo Korematsu,Hiroaki Miyahara,Akiyoshi Kakita,Tatsuro Izumi
発行年月	2014/11
概要	Introduction: Because the optic nerve is mainly comprised from phospholipids such as phosphatidylcholine, the association between optic neuritis, anti-phospholipids antibodies and vaccination was examined.Subjects: Two female pediatric patients suddenly presented bilateral optic neuritis after administration of trivalent inactivated influenza vaccine.Methods: These two patients and another 11 patients with central nervous system demyelinating diseases were examined these anti-phospholipids antibodies. And immune histopathology was examined using serum derived from a patient with optic neuritis.Results: High serum titer of anti-phosphatidylcholine antibody levels were detected during acute phase in patients with optic neuritis. The patient's serum IgG antibodies were found to have stained the capillary endotheliums in the preserved autopsied optic nerve. Patients with optic neuritis had significantly elevated serum levels of anti-phosphatidylcholine antibody in comparison to the other patients without optic neuritis.Conclusion: Anti-phosphatidylcholine antibodies may be one of the causes of optic neuritis. (C) 2014 Elsevier Ltd. All rights reserved.
DOI	10.1016/j.vaccine.2014.09.053
PMID	25285881