コレマツ　セイゴ   KOREMATSU Seigo   是松　聖悟    所属   埼玉医科大学  医学部 総合医療センター　小児科（小児科､総合周産期母子医療センター新生児科、小児救命救急センター）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Efficacy of fluticasone metered-dose inhaler and dry powder inhaler for pediatric asthma.
掲載誌名	正式名：Pediatrics international : official journal of the Japan Pediatric Society ISSNコード：13288067
出版社	BLACKWELL PUBLISHING
巻・号・頁	50(1),103-8頁
著者・共著者	Hiroaki Miyahara,Seigo Korematsu,Tomokazu Nagakura,Tatsuro Izumi
発行年月	2008/02
概要	BACKGROUND: For the treatment of bronchial asthma, two types of fluticasone inhaler devices are available, namely, metered-dose inhaler with spacer (MDI-S) and the dry powder inhaler (DPI). The former is recommended for young children with a low peak inspiratory flow (PIF) and the latter for adolescents and adults. But the difference in the therapeutic efficacy between them has been studied only rarely in adolescent patients. METHODS: In the present study, 21 post-elementary school-age patients with moderate persistent bronchial asthma (age 8-15 years, 10.3 +/- 2.1 years), who all had a sufficient PIF of 114 +/- 29 L/min, were examined in order to compare the two types of fluticasone inhalers. Eleven of 21 patients inhaled 200 microg/day Flutide using the MDI-S twice daily for 1 month in the first month, and the same dose using the DPI for the next month.The other 10 patients inhaled the opposite regimens. At the end of the each treatment, spirometry was examined. RESULTS: Measurements done before therapy and then at the end of MDI-S and DPI therapy, respectively, were as follows: forced expiratory volume in 1 s (FEV(1.0)), 72.4 +/- 18.2%, 91.5 +/- 18.2% and 84.1 +/- 16.3% (MDI-S
DOI	10.1111/j.1442-200X.2007.02523.x
PMID	18279216