コレマツ　セイゴ   KOREMATSU Seigo   是松　聖悟    所属   埼玉医科大学  医学部 総合医療センター　小児科（小児科､総合周産期母子医療センター新生児科、小児救命救急センター）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The characterization of cerebrospinal fluid and serum cytokines in patients with Kawasaki disease.
掲載誌名	正式名：The Pediatric infectious disease journal ISSNコード：08913668
出版社	LIPPINCOTT WILLIAMS&WILKINS
巻・号・頁	26(8),750-3頁
著者・共著者	Seigo Korematsu,Shin-ichi Uchiyama,Hiroaki Miyahara,Tomokazu Nagakura,Naho Okazaki,Tatsuya Kawano,Masanobu Kojo,Tatsuro Izumi
発行年月	2007/08
概要	BACKGROUND: The central nervous system (CNS) inflammation of Kawasaki disease (KD) has not been sufficiently evaluated in spite of the complications of irritability and CSF pleocytosis. PATIENTS AND METHODS: Cerebrospinal fluid (CSF) and serum inflammatory cytokine values were simultaneously examined in 10 patients (2.6 +/- 2.1 year of age) during the acute phase. They were all irritable and demonstrated mild consciousness disturbance. RESULTS: The CSF IL6 was elevated (>3.0 pg/mL) in 6 patients, and 4 of them showed higher CSF than serum values. The CSF sTNFR1 was elevated (>0.5 microg/mL) in 6 patients, and 1 showed higher CSF than serum values. These CSF cytokine (IL6; 81.4 +/- 192.8 pg/mL, sTNFR1; 1.1 +/- 0.8 microg/mL) and CSF/serum ratio (IL6; 2.8 +/- 5.2, sTNFR1 0.4 +/- 0.4) in patients with KD were the same as those of patients with acute encephalitis/acute encephalopathy. CONCLUSIONS: The differences in the inflammatory cytokine value between CSF and serum suggest that the degree of systemic vasculitis is different between CSF and the circulating blood, and some patients with KD showed a higher degree of CSF inflammation.
DOI	10.1097/INF.0b013e3180f61708
PMID	17848892