コレマツ　セイゴ   KOREMATSU Seigo   是松　聖悟    所属   埼玉医科大学  医学部 総合医療センター　小児科（小児科､総合周産期母子医療センター新生児科、小児救命救急センター）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The indication and effectiveness of low-dose erythromycin therapy in pediatric patients with bronchial asthma.
掲載誌名	正式名：Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology ISSNコード：09056157
出版社	WILEY-BLACKWELL
巻・号・頁	21(3),489-92頁
著者・共著者	Seigo Korematsu,Kyoko Yamamoto,Tomokazu Nagakura,Hiroaki Miyahara,Naho Okazaki,Kensuke Akiyoshi,Tomoki Maeda,So-ichi Suenobu,Tatsuro Izumi
発行年月	2010/05
概要	To elucidate the mechanisms of intractable pediatric bronchial asthma and the indication of low-dose erythromycin (EM) therapy, the serum chemokine levels of and the angiogenic factor were evaluated in 55 pediatric patients with bronchial asthma; 7.4 +/- 3.5 yr old, who had been treated with inhaled steroid, leukotriene receptor antagonist, theophylline and others for more than a year. Both the levels of interleukin (IL) 8 (p = 0.036) and vascular endothelial growth factor (VEGF) (p = 0.005) were higher in patients with severe type than those of patients with the milder type, while other chemokine levels such as serum eotaxin and MCP1 did not show the correlation with the severityof bronchial asthma. Induction of therapy with low-dose EM induced improvement of the clinical symptoms in patients with severe type and decrease of their serum chemokine levels: IL8; from 736 +/- 88 to 75 +/- 85 pg/ml (p<0.0005), and VEGF; from 352.0 +/- 160.5 to 132.2 +/- 59.9 pg/ml (p = 0.021) within the next 6 months. Moreover, low-dose EM resulted in a decreased daily peak-trough fluctuation rate of the serum theophylline concentration; (C(max )- C(min))/C(min), from 1.3 +/- 0.5 to 0.5 +/- 0.3, whi
DOI	10.1111/j.1399-3038.2009.00941.x
PMID	20546525