マエシマ　アキト   MAESHIMA Akito   前嶋　明人    所属   埼玉医科大学  医学部 総合医療センター　腎・高血圧内科    職種   教授
論文種別	学術雑誌(症例報告)
言語種別	英語
査読の有無	査読あり
表題	Successful treatment of severe crescentic lupus nephritis by multi-target therapy using tacrolimus and mycophenolate mofetil.
掲載誌名	正式名：CEN case reports 略　 称：CEN Case Rep
掲載区分	国内
巻・号・頁	4(2),126-130頁
著者・共著者	Mochizuki Kaori, Kayakabe Ken, Hiromura Keiju, Ando Masayasu, Sakurai Noriyuki, Ikeuchi Hidekazu, Sakairi Toru, Kaneko Yoriaki, Maeshima Akito, Nojima Yoshihisa
発行年月	2015/11
概要	Treatment of severe lupus nephritis (LN) has been controversial, and according to recent guidelines and recommendations, cyclophosphamide still remains a first-line therapy. Herein, we present the case of a 37-year-old female patient who developed rapidly progressive glomerulonephritis, which was histologically diagnosed as class IV + V LN, with a large number of cellular to fibrocellular crescents (62 % of glomeruli). Although the patient was considered to have the most severe form of LN, complete remission was achieved within 6 months by multi-target therapy using tacrolimus and mycophenolate mofetil combined with methylprednisolone pulse therapy. Our experience suggests that multi-target therapy could be a potential treatment option for patients withsevere crescentic LN.
DOI	10.1007/s13730-014-0151-0
PMID	28509085