マエシマ　アキト   MAESHIMA Akito   前嶋　明人    所属   埼玉医科大学  医学部 総合医療センター　腎・高血圧内科    職種   教授
論文種別	学術雑誌(症例報告)
言語種別	英語
査読の有無	査読あり
表題	Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review.
掲載誌名	正式名：Case reports in rheumatology 略　 称：Case Rep Rheumatol
巻・号・頁	2018,6873276頁
著者・共著者	Ikeuchi Hidekazu, Koinuma Kana, Nakasatomi Masao, Sakairi Toru, Kaneko Yoriaki, Maeshima Akito, Yamazaki Yuichi, Okamoto Hiroaki, Mimura Toshihide, Mochida Satoshi, Nojima Yoshihisa, Hiromura Keiju
発行年月	2018
概要	Hepatitis E is an acute self-limiting disease caused by hepatitis E virus (HEV). Recent reports show that HEV can induce chronic hepatitis or be reactivated in immunocompromised hosts. We report a 63-year-old woman with rheumatoid arthritis (RA) who developed hepatitis E during treatment with tocilizumab. Analysis of serially stocked serum samples confirmed that hepatitis was caused by primary infection with HEV and not by viral reactivation. Her liver function improved after discontinuing tocilizumab and remained within the normal range without reactivation of HEV for>5 years after restarting tocilizumab. We also reviewed the published cases of hepatitis E that developed during RA treatment.
DOI	10.1155/2018/6873276
PMID	30147981