マエシマ　アキト   MAESHIMA Akito   前嶋　明人    所属   埼玉医科大学  医学部 総合医療センター　腎・高血圧内科    職種   教授
論文種別	学術雑誌(症例報告)
言語種別	英語
査読の有無	査読あり
表題	Different Effects on Fluid Distribution between Tolvaptan and Furosemide in a Liver Cirrhosis Patient with Chronic Kidney Disease.
掲載誌名	正式名：Internal medicine (Tokyo, Japan) 略　 称：Intern Med
巻・号・頁	58(11),1587-1591頁
著者・共著者	Nagayama Izumi, Masuda Takahiro, Nakagawa Saki, Murakami Takuya, Ohara Ken, Matsuoka Ryo, Kobayashi Takahisa, Maeshima Akito, Akimoto Tetsu, Saito Osamu, Muto Shigeaki, Nagata Daisuke
発行年月	2019/06/01
概要	A 73-year-old man with liver cirrhosis and advanced chronic kidney disease was admitted to our hospital due to bilateral lower leg edema and appetite loss. Furosemide to treat fluid retention markedly decreased extracellular water compared with intracellular water, but the addition of tolvaptan equally decreased both with a greater diuretic response than furosemide alone. Furthermore, tolvaptan administration increased the plasma colloid osmotic pressure, which might facilitate the shift of fluid from the extravascular space to the intravascular space. This is the first case showing different effects on the fluid distribution between furosemide and additional tolvaptan in the same patient.
DOI	10.2169/internalmedicine.2174-18
PMID	30713322