マエシマ　アキト   MAESHIMA Akito   前嶋　明人    所属   埼玉医科大学  医学部 総合医療センター　腎・高血圧内科    職種   教授
論文種別	学術雑誌(総説)
言語種別	英語
査読の有無	査読なし
表題	The role of the activin-follistatin system in the developmental and regeneration processes of the kidney.
掲載誌名	正式名：Cytokine&growth factor reviews 略　 称：Cytokine Growth Factor Rev
掲載区分	国外
巻・号・頁	12(4),289-298頁
著者・共著者	Maeshima A, Nojima Y, Kojima I
発行年月	2001/12
概要	Regeneration processes in many tissues are modulated by various factors, which are involved in their organogenesis. Activin A, a member of the TGF-beta superfamily, inhibits branching tubulogenesis of the kidney in organ culture system as well as in in vitro tubulogenesis model. On the other hand, follistatin, an antagonist activin A, reverses the effect of activin A on kidney development, induces branching tubulogenesis, and also promotes tubular regeneration after ischemia/reperfusion injury by blocking the action of endogenous activin A. The activin-follistatin system is one of the important regulatory systems modulating developmental and regeneration processes of the kidneys.
DOI	10.1016/s1359-6101(01)00010-7
PMID	11544099