マエシマ　アキト   MAESHIMA Akito   前嶋　明人    所属   埼玉医科大学  医学部 総合医療センター　腎・高血圧内科    職種   教授
論文種別	学術雑誌(総説)
言語種別	英語
査読の有無	査読なし
表題	Label-retaining cells in the kidney: origin of regenerating cells after renal ischemia.
掲載誌名	正式名：Clinical and experimental nephrology 略　 称：Clin Exp Nephrol
掲載区分	国内
巻・号・頁	11(4),269-274頁
著者・共著者	Maeshima Akito
発行年月	2007/12
概要	The kidney is capable of regeneration. In response to a variety of insults, renal epithelial tubular cells dedifferentiate into an immature phenotype, proliferate, migrate to the injured area, and redifferentiate into mature polarized epithelial cells. In animal models of acute kidney injury induced by renal ischemia or renal toxins, various growth factors, transcription factors, chemokines, and extracellular matrix components have been demonstrated to be involved in the regeneration process. Recent research has suggested the existence of renal stem/progenitor cells in the kidney and their involvement in renal regeneration. In this review, we willfocus on the mechanisms of tubular regeneration after kidney injury, particularly on label-retaining cells actively engaged in this process, and discuss their potential as targets of regenerative therapy for various kidney diseases.
DOI	10.1007/s10157-007-0500-9
PMID	18085386