マエシマ　アキト   MAESHIMA Akito   前嶋　明人    所属   埼玉医科大学  医学部 総合医療センター　腎・高血圧内科    職種   教授
論文種別	学術雑誌(総説)
言語種別	英語
査読の有無	査読なし
表題	Activin A: autocrine regulator of kidney development and repair.
掲載誌名	正式名：Endocrine journal 略　 称：Endocr J
掲載区分	国内
巻・号・頁	55(1),1-9頁
著者・共著者	Maeshima Akito, Miya Masaaki, Mishima Keiichiro, Yamashita Shin, Kojima Itaru, Nojima Yoshihisa
発行年月	2008/03
概要	The research described in this review suggests a novel and important role for activin A in the developmental and repair processes of the kidney (Table 1). The results obtained in these studies indicate that activin A is a negative regulator of kidney development and plays an essential part in kidney diseases, such as acute renal failure or renal fibrosis. It is also possible that activin A is a key player in the pathophysiological processes of other kidney diseases, such as congenital urogenital abnormalities, renal cystic disease and renal cell carcinoma. Activin A is thus a potential target for therapeutic interventions in kidney diseases. To address this issue, more detailed analysis on the regulation of activin production, modulation of activin activity and activin target genes is required.
DOI	10.1507/endocrj.kr-113
PMID	17827789