ハトウ　タイ   HATO Tai   羽藤　泰    所属   埼玉医科大学  医学部 総合医療センター　呼吸器外科    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma
掲載誌名	正式名：Hepatology 略　 称：Hepatology ISSNコード：15273350
掲載区分	国外
出版社	Wiley
巻・号・頁	71(4),1247-1261頁
著者・共著者	Kohei Shigeta, Meenal Datta, Tai Hato, Shuji Kitahara, Ivy X Chen, Aya Matsui, Hiroto Kikuchi, Emilie Mamessier, Shuichi Aoki, Rakesh R Ramjiawan, Hiroki Ochiai, Nabeel Bardeesy, Peigen Huang, Mark Cobbold, Andrew X Zhu, Rakesh K Jain, Dan G Duda
発行年月	2019/10/14
概要	Activation of the antitumor immune response using programmed death receptor-1 (PD-1) blockade showed benefit only in a fraction of patients with hepatocellular carcinoma (HCC). Combining PD-1 blockade with antiangiogenesis has shown promise in substantially increasing the fraction of patients with HCC who respond to treatment, but the mechanism of this interaction is unknown. We show that dual anti-PD-1/VEGFR-2 therapy has a durable vessel fortification effect in HCC and can overcome treatment resistance to either treatment alone and increase overall survival in both anti-PD-1 therapy-resistant and anti-PD-1 therapy-responsive HCC models.