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タジマ ヒロユキ
TAJIMA Hiroyuki
田島 廣之 所属 埼玉医科大学 医学部 国際医療センター 放射線科（放射線腫瘍科、画像診断、核医学科） 職種 特任教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Urinary excretion of vasoactive factors following contrast media exposure in humans |
| 掲載誌名 | 正式名：NEPHRON CLINICAL PRACTICE ISSNコード：16602110 |
| 出版社 | KARGER |
| 巻・号・頁 | 101(3),150-154頁 |
| 著者・共著者 | R Murakami,T Kumazaki,H Tajima,H Hayashi,T Kuwako,K Hakozaki,T Kiriyama |
| 発行年月 | 2005 |
| 概要 | Background: Radiographic contrast media ( CM) induce renal vasoconstriction and may initiate induced nephropathy. Endothelin ( ET), a vasoconstrictor, and nitric oxide ( NO), a vasodilator, which are synthesized in the kidney by the vascular endothelium as well as by tubular epithelial and glomerular mesangial cells, are key modulators of renal circulation after CM administration. Intravascular CM, in addition, induces pronounced diuresis and natriuresis. The aim of the present study was to evaluate and compare changes in endogenous vasoactive mediators and contrast-induced natriuresis after CM administration. Methods: Diagnostic angiographic procedures were performed in 14 patients ( 9 males and 5 females) using the non-ionic CM Iopamidol. Before and immediately after angiography, venous blood and urine samples were obtained. The urinary excretion of ET-1 and nitrates/ nitrites (NOx), and the fractional excretion of sodium (FENa) were measured and analyzed. Results: The urinary excretion of both ET-1 and NOx increased significantly ( p< 0.05) after angiography, and urinary ET-1 and NOx excretion was correlated with an increase in FENa ( p< 0.05). Conclusion: Exposure to CM |
| DOI | 10.1159/000086715 |