タジマ　ヒロユキ   TAJIMA Hiroyuki   田島　廣之    所属   埼玉医科大学  医学部 国際医療センター　放射線科（放射線腫瘍科、画像診断、核医学科）    職種   特任教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Changes in pelvic and systemic platinum concentrations during negative-balance isolated pelvic perfusion: correlation between platinum concentration and method of administration in a pig model
掲載誌名	正式名：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY ISSNコード：01715216
出版社	SPRINGER
巻・号・頁	133(7),417-422頁
著者・共著者	Satoru Murata,Hiroyuki Tajima,Yutaka Abe,Shiro Onozawa,Fumio Uchiyama,Hiromitsu Hayashi,Ryoji Kimata,Kazuhiro Nomura
発行年月	2007/07
概要	Purpose To assess the effect of altering the method of administration during negative-balance isolated pelvic perfusion (NIPP) on the platinum concentration in the pelvic or systemic circulation.Methods Twenty female pigs were used in this study. The abdominal aorta and the infra-renal vena cava were occluded with two balloon catheters and blood in the extracorporeal circuit was circulated with twin rotary pumps. NIPP was then performed with cisplatin (5 mg/kg) in 15 pigs. Three types of NIPP administration method (group A: 1 bolus, B: 2 same doses boluses, C: 3 same doses boluses) were used, five pigs being subjected to each treatment. The remaining five pigs were administered cisplatin systemically as a control study (group D). The platinum concentrations in the pelvic and systemic circulation were measured and compared.Results (1) Pelvic circulation: There was a tendency for the platinum concentration to increase as the bolus time decreased. The platinum concentration in groups A and B was significantly (P< 0.05) higher than that in group C. Significantly differences (P< 0.05) between groups A and B until 10 min after the start of NIPP. (2) Systemic circulation: Signif
DOI	10.1007/s00432-006-0168-7