タジマ　ヒロユキ   TAJIMA Hiroyuki   田島　廣之    所属   埼玉医科大学  医学部 国際医療センター　放射線科（放射線腫瘍科、画像診断、核医学科）    職種   特任教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Large volume loading to prevent cisplatin-induced nephrotoxicity during negative-balance isolated pelvic perfusion
掲載誌名	正式名：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY ISSNコード：01715216
出版社	SPRINGER
巻・号・頁	133(10),741-747頁
著者・共著者	Keiko Nakazato,Chol Kim,Katsuyuki Terajima,Satoru Murata,Hitoshi Fujitani,Kazuhiro Nakanishi,Hiroyuki Tajima,Tatsuo Kumazaki,Atsuhiro Sakamoto
発行年月	2007/10
概要	Purpose Negative-balance isolated pelvic perfusion (NIPP) is used to administer high doses of anticancer drugs such as cisplatin to patients with advanced cancer of the pelvic region. Although the drugs are intended to be specifically delivered to the pelvis, their leakage into the systemic circulation can cause acute renal failure. This study examines the loading volume required for preservation of renal function during anesthesia of NIPP.Methods Pelvic cancer patients were assigned to NIPP according to its enrollment criteria. Patients with heart failure, uncontrollable hypertension, renal failure, pulmonary disease or contraindication for the contrast media were excluded. We compared the current anesthesia management regime with a previous protocol, with regard to the loading volume and renal function as assessed by the calculated glomerular filtration rate (GFR). The correlation between the total loading volume and the GFR ratio (GFR after NIPP/GFR before NIPP) was evaluated to define adequate volume loading.Results The GFR ratios were 0.86 +/- 0.29 and 1.12 +/- 0.25 for the previous and current procedures, respectively. The regression line showed that a minimum loading volum
DOI	10.1007/s00432-007-0217-x
PMID	17503082