イタザワ　トシコ   ITAZAWA TOSHIKO   板澤　寿子    所属   埼玉医科大学  医学部 小児科（小児科、新生児科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Theophylline metabolism in acute asthma with MxA-indicated viral infection.
掲載誌名	正式名：Pediatrics international : official journal of the Japan Pediatric Society ISSNコード：13288067
出版社	BLACKWELL PUBLISHING
巻・号・頁	48(1),54-7頁
著者・共著者	Toshiko Itazawa,Yuichi Adachi,Motokazu Nakabayashi,Tatsuya Fuchizawa,Gyokei Murakami,Toshio Miyawaki
発行年月	2006/02
概要	BACKGROUND: Although viral infection might alter theophylline metabolism in acute asthma, there are some difficulties in detecting infection due to various kinds of viruses in a clinical setting. METHODS: To evaluate the usefulness of assessment of MxA protein in acute asthma exacerbated by viral infection, MxA protein expression in lymphocytes was assayed by flow cytometric analysis in whole peripheral blood in 21 children (aged 0-6 years) receiving continuous theophylline infusion for management of asthma attack. Serum theophylline levels were measured at 24 and 72 h after initiating theophylline infusion. RESULTS: At the beginning of theophylline infusion, 11 children had increased expression of MxA protein, indicating viral infected states. After 24 h continuous infusion, there were no differences in theophylline levels between MxA-negative and MxA-positive groups. After 72 h infusion, the mean theophylline level of MxA-positive children was significantly higher than that of MxA-negative children (9.7 +/- 2.2 microg/mL vs 7.3 +/- 1.6 microg/mL). The ratio of theophylline clearance at 72 h to that at 24 h in the MxA-positive group was significantly lower than that of the MxA-neg
DOI	10.1111/j.1442-200X.2006.02172.x
PMID	16490071