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イノウエ イクオ
INOUE Ikuo
井上 郁夫 所属 埼玉医科大学 医学部 教職員・学生健康推進センター 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Long-Term Effects of Ipragliflozin on Diabetic Nephropathy and Blood Pressure in Patients With Type 2 Diabetes: 104-Week Follow-up of an Open-Label Study. |
| 掲載誌名 | 正式名：Journal of clinical medicine research 略 称：J Clin Med Res |
| 掲載区分 | 国外 |
| 巻・号・頁 | 10(9),679-687頁 |
| 著者・共著者 | Ito Daisuke, Inoue Kazuyuki, Sumita Takashi, Hamaguchi Keiko, Kaneko Kimie, Yanagisawa Morifumi, Inukai Kouichi, Inoue Ikuo, Noda Mitsuhiko, Shimada Akira |
| 発行年月 | 2018/09 |
| 概要 | Background:In our previous study, we investigated the efficacy of ipragliflozin, a sodium-glucose cotransporter (SGLT) 2 inhibitor on diabetic nephropathy in patients with type 2 diabetes and demonstrated that ipragliflozin significantly improved diabetic nephropathy in addition to reducing HbA1c and body weight. Herein, we conducted post-trial monitoring to determine whether these lowering effects on blood glucose and body weight or the beneficial effects on diabetic nephropathy were maintained long-term (104 weeks) after starting ipragliflozin treatment.Results: the estimated glomerular filtration rate (eGFR) was restored to near the baseline level at 104 weeks. Notably, in patients with diabetic nephropathy, the median urinary albumin-to-creatinine ratio (UACR) was significantly decreased from 119.2 (98.9 - 201.8) at baseline to 36.9 (19.7 - 204.7) mg/gCr at 104 weeks. In addition, eGFR was stable for 104 weeks, showing no decrease. |
| DOI | 10.14740/jocmr3491w |
| PMID | 30116437 |