イノウエ　イクオ   INOUE Ikuo   井上　郁夫    所属   埼玉医科大学  医学部 教職員・学生健康推進センター    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Body weight threshold for sudden onset of ketosis may exist in ketosis-prone type 2 diabetes.
掲載誌名	正式名：Journal of diabetes investigation 略　 称：J Diabetes Investig
掲載区分	国外
巻・号・頁	11(2),499-501頁
著者・共著者	Satomura Atsushi, Oikawa Yoichi, Haisa Akifumi, Inoue Ikuo, Noda Mitsuhiko, Shimada Akira
発行年月	2019/07
概要	Ketosis-prone type 2 diabetes (KPD) is recognized as atypical diabetes. These patients are often male, characterized by obesity, sudden onset of ketosis, and transient decrease in insulin secretion capacity which can be recovered with temporal insulin therapy. Here, we report a male patient with KPD who could be followed up for 8 years. During the follow-up period, his body weight fluctuated and he experienced four episodes of critical ketosis recurrence in association with body weight gain. He could discontinue insulin therapy after each ketosis within the first 4 years, but thereafter, he had to continue insulin therapy because of decreased insulin secretion capacity. Interestingly, his peak body weight just before the episode of repeated ketosis gradually decreased, and the insulin secretion capacity after the recovery from repeated ketosis decreased in parallel with his peak body weight. This long-term clinical course may be a clue to understand the pathophysiology of KPD.
DOI	10.1111/jdi.13120
PMID	31339666