ハトウ　タイ   HATO Tai   羽藤　泰    所属   埼玉医科大学  医学部 総合医療センター　呼吸器外科    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
掲載誌名	正式名：International journal of radiation oncology, biology, physics 略　 称：Int J Radiat Oncol Biol Phys
掲載区分	国外
巻・号・頁	101(5),1222-1225頁
著者・共著者	Grassberger Clemens, Hong Theodore S, Hato Tai, Yeap Beow Y, Wo Jennifer Y, Tracy Mark, Bortfeld Thomas, Wolfgang John A, Eyler Christine E, Goyal Lipika, Clark Jeffrey W, Crane Christopher H, Koay Eugene J, Cobbold Mark, DeLaney Thomas F, Jain Rakesh K, Zhu Andrew X, Duda Dan G
発行年月	2018/08
概要	Irradiation may have significant immunomodulatory effects that impact tumor response and could potentiate immunotherapeutic approaches. We prospectively investigate circulating lymphoid cell population fractions during hypofractionated proton therapy (HPT) in blood samples of liver cancer patients and to explore their association with survival.We collected serial blood samples before treatment and at days 8 and 15 of HPT from 43 patients with liver cancer-22 with hepatocellular carcinoma (HCC) and 21 with intrahepatic cholangiocarcinoma (ICC)-enrolled in a phase 2 clinical trial. Longer OS was significantly correlated with greater CD4+. Antitumor immunity may depend on maintenance of a sufficiently high number of activated CTLs during HPT in HCC patients and CD4+.
DOI	10.1016/j.ijrobp.2018.04.026
PMID	29859792