トクモト　ヤスヒト   TOKUMOTO Yasuhiro   徳元　康人    所属   埼玉医科大学  医学部 アドミッションセンター    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1
掲載誌名	正式名：Scientific Reports
出版社	Springer
巻・号・頁	7,1019頁
著者・共著者	Yasuhito Tokumoto, Shinpei Tamaki, Yasuaki Kabe, Keiyo Takubo, Makoto Suematsu
発行年月	2017/04
概要	In developing rat optic nerves, thyroid hormone inhibits the proliferation of perinatal oligodendrocyte precursor cells (OPCs). In normoxia, cells differentiate into oligodendrocytes. On the other hand, in a hypoxic niche, quiescent OPCs sustain their potential capacities of proliferation and differentiation as adult somatic stem cells (Adult OPCs). Hypoxia-inducible factors-mediated expression of transcription factor Runx1 and resultant p15/INK4b induction contributes to development of adult OPCs.
PMID	28432293
researchmap用URL	https://www.nature.com/articles/s41598-017-01023-9