ハヤシ　ムツミ   HAYASHI Mutsumi   林　睦    所属   埼玉医科大学  医学部 病理学    職種   助教
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Blockade of CD26 Signaling Inhibits Human Osteoclast Development
掲載誌名	正式名：J Bone Mineral Research
掲載区分	国外
巻・号・頁	29(11),2439-2455頁
著者・共著者	Nishida H, Suzuki H, Madokoro H, Hayashi M, Morimoto C, Sakamoto M, Yamada T
発行年月	2014/11
概要	We herein show that CD26 is preferentially expressed on normal human OCs and is intensely expressed on activated human OCs in osteolytic bone alterations. The humanized anti-CD26 monoclonal antibody, huCD26mAb, impaired the formation and function of tartrate-resistant acid phosphatase (TRAP)/CD26 positive multi-nucleated OCs with maturation in the manner of dose-dependency. It was revealed that huCD26mAb inhibits early OC differentiation via the inactivation of MKK3/6, p38 MAPK and subsequent dephospho rylation of microphthalmia-associated transcription factor.