ヤマダ　タケト   YAMADA Taketo   山田　健人    所属   埼玉医科大学  医学部 病理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Significant roles of the (pro)rennin receptor in integrity of vascular smooth muscle cells
掲載誌名	正式名：Hypertension Research
巻・号・頁	37(9),830-835頁
著者・共著者	Kurauchi-Mito A, Ichihara A, Bokuda K, Sakoda M, Kinouchi K, Yaguchi T, Yamada T, Sun-Wada GH, Wada Y, Itoh H
発行年月	2014/09
概要	In this study, smooth muscle cell-specific (P)RR/Atp6ap2 conditional knockout mice were generated. Smooth muscle cell-specific ablation of the (P)RR resulted in nonatherogenic sclerosis in the abdominal aorta. The deletion of the (P)RR did not affect ambulatory blood pressure levels. In cultured murine vascular smooth muscle cells (VSMCs), ablation of the (P)RR suppressed the expression of the Vo subunit c of the vacuolar H(+)-ATPase and impaired the cell recycling system, leading to autophagic cell death. In addition, loss of the (P)RR in VSMCs induced the expression of monocyte chemotactic protein-1 and interleukin-6 mRNAs. These results suggest that the (P)RR is essential for cell survival and downregulation of vascular inflammation in murine VSMCs through maintaining normal function of the vacuolar H(+)-ATPase.