ハセベ　タカヒロ   HASEBE Takahiro   長谷部　孝裕    所属   埼玉医科大学  医学部 国際医療センター　乳腺腫瘍科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Grading system for blood vessel tumor emboli of invasive ductal carcinoma of the breast.
掲載誌名	正式名：Human Pathology
出版社	ELSEVIER
巻・号・頁	46,906-916頁
著者・共著者	Sugiyama M, Hasebe T, Shimada H, Takeuchi H, Shimizu K, Shimizu M, Yasuda M, Ueda S, Shigekawa T, Osaki A, Saeki T.
発行年月	2015/06
概要	We classified 263 invasive ductal carcinomas into the following 3 grades according to the numbers ofmitotic and apoptotic figures in tumor cells located in blood vessels within 1 high-power field: grade 0, no blood vessel invasion; grade 1, absence of mitotic figures and presence of any number of apoptotic figures, or 1 mitotic figure and 0 to 2 apoptotic figures; and grade 2, 1 mitotic figure and 3 ormore apoptotic figures, or 2 or more mitotic figures and 1 or more apoptotic figures. Multivariate analyses with well-known prognostic factors demonstrated that grade 2 blood vessel tumor emboli significantly increased the hazard ratios for tumor recurrence independent of the nodal status, pathological TNMstage, hormone receptor status, orHER2 status. The presently reported grading system for blood vessel tumor emboli is the strongest histologic factor for accurate prediction of the outcome of patients with invasive ductal carcinoma of the breast.