教員情報 - 雷　小峰 | 埼玉医科大学

（最終更新日：2023-05-02 09:20:15）

  ライ　ショウホウ   RAI Shouho
  雷　小峰
   所属   埼玉医科大学医学部国際医療センター　皮膚科（皮膚腫瘍科）

職種助教

■ 研究課題・受託研究・科研費

1.	2012～2013	新規大動脈瘤形成抑制分子Ｈｉｃー５の機能解析
2.	2014～2016	TGF-β1誘導性分子Hic-5を標的とした大動脈瘤の治療へ向けた基礎研究
3.	2017～2019	星細胞活性化分子を軸とした新規膵疾患治療標的分子の確立
4.	2020/04～2023/03	TGF-β 誘導性分子を標的とした新規肺線維症治療戦略の構築基盤研究(C)

■ 受賞履歴

1.	2009	XV International Symposium on Atherosclerosis Young Investigator Award
2.	2010	日本動脈硬化学会 Journal of Atherosclerosis and Thrombosis (JAT) 2010年度優秀論文
3.	2011	公益財団法人昭和大学医学・医療振興財団医学研究助成
4.	2012	日本血管生物医学会 IVBM2012 トラベルアワード
5.	2012	第44回日本動脈硬化学会総会学術集会優秀ポスター賞
6.	2013	公益財団法人日中医学協会共同研究助成
7.	2014	公益財団法人武田科学振興財団医学系研究奨励
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■ 学術雑誌

1.	学術雑誌(原著)	STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases. 2021/07/06
2.	学術雑誌(原著)	Hic-5 is required for activation of pancreatic stellate cells and development of pancreatic fibrosis in chronic pancreatitis. 2020/11/05
3.	学術雑誌(原著)	Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5. 2019/10/31
4.	学術雑誌(原著)	Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms. 2019/09/30
5.	学術雑誌(原著)	Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis. 2019/04/02
6.	学術雑誌(原著)	Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells 2018/12/01
7.	学術雑誌(原著)	The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling 2018/03/01
8.	学術雑誌(原著)	Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing 2016/09
9.	学術雑誌(原著)	The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe 2016/09
10.	学術雑誌(原著)	Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice 2016/01
11.	学術雑誌(原著)	Calpastatin Counteracts Pathological Angiogenesis by Inhibiting Suppressor of Cytokine Signaling 3 Degradation in Vascular Endothelial Cells 2015/03
12.	学術雑誌(原著)	Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis 2015/03
13.	学術雑誌(原著)	NADPH Oxidase Deficiency Exacerbates Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice 2014/11
14.	学術雑誌(原著)	Identification of Hic-5 as a Novel Scaffold for the MKK4/p54 JNK Pathway in the Development of Abdominal Aortic Aneurysms 2014/06
15.	学術雑誌(原著)	ACAT1-associated Late Endosomes/Lysosomes Significantly Improve Impaired Intracellular Cholesterol Metabolism and the Survival of Niemann-Pick Type C Mice 2014
16.	学術雑誌(原著)	m-Calpain Induction in Vascular Endothelial Cells on Human and Mouse Atheromas and Its Roles in VE-Cadherin Disorganization and Atherosclerosis 2011/12
17.	学術雑誌(原著)	Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204) 2011/08
18.	学術雑誌(原著)	Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma 2010/08
19.	学術雑誌(原著)	Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity 2010/06
20.	学術雑誌(原著)	Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappa B (RANK) 2010/01
21.	学術雑誌(原著)	Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages 2009/11
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