イタザワ トシコ   ITAZAWA TOSHIKO
  板澤 寿子
   所属   埼玉医科大学  医学部 小児科(小児科、新生児科)
   職種   准教授
論文種別 学術雑誌(原著)
言語種別 英語
査読の有無 査読あり
表題 Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation.
掲載誌名 正式名:Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
巻・号・頁 48(12),1676-1687頁
著者・共著者 Koa Hosoki,Pawel Jaruga,Toshiko Itazawa,Leopoldo Aguilera-Aguirre,Erdem Coskun,Tapas K Hazra,Istvan Boldogh,Miral Dizdaroglu,Sanjiv Sur
発行年月 2018/12
概要 BACKGROUND: Ragweed pollen extract (RWPE) induces TLR4-NFκB-CXCL-dependent recruitment of ROS-generating neutrophils to the airway and OGG1 DNA glycosylase-dependent excision of oxidatively induced 8-OH-Gua DNA base lesions from the airway epithelial cell genome. Administration of free 8-OH-Gua base stimulates RWPE-induced allergic lung inflammation. These studies suggest that stimulation of innate receptors and their adaptor by allergenic extracts initiates excision of a set of DNA base lesions that facilitate innate/allergic lung inflammation. OBJECTIVE: To test the hypothesis that stimulation of a conserved innate receptor/adaptor pathway by allergenic extracts induces excision of a set of pro-inflammatory oxidatively induced DNA base lesions from the lung genome that stimulate allergic airway inflammation.
DOI 10.1111/cea.13284
PMID 30244512