所属 埼玉医科大学 医学部 神経精神科・心療内科 職種 教授
|Genetic influences on prefrontal activation during a verbal fluency task in adults: A twin study based on multichannel near-infrared spectroscopy
|ACADEMIC PRESS INC ELSEVIER SCIENCE
|Eisuke Sakakibara,Ryu Takizawa,Yukika Nishimura,Shingo Kawasaki,Yoshihiro Satomura,Akihide Kinoshita,Shinsuke Koike,Kohei Marumo,Masaru Kinou,Mamoru Tochigi,Nao Nishida,Katsushi Tokunaga,Satoshi Eguchi,Syudo Yamasaki,Tatsunobu Natsubori,Norichika Iwashiro,Hideyuki Inoue,Yosuke Takano,Kunio Takei,Motomu Suga,Hidenori Yamasue,Junko Matsubayashi,Kenji Kohata,Chie Shimojo,Shiho Okuhata,Toshiaki Kono,Hitoshi Kuwabara,Ayaka Ishii-Takahashi,Yuki Kawakubo,Kiyoto Kasai
|Near-infrared spectroscopy (NIRS) studies have reported that prefrontal hemodynamic dysfunction during executive function tasks may be a promising biomarker of psychiatric disorders, because its portability and noninvasiveness allow easy measurements in clinical settings. Here, we investigated the degree to which prefrontal NIRS signals are genetically determined. Using a 52-channel NIRS system, we monitored the oxy-hemoglobin (oxy-Hb) signal changes in 38 adult pairs of right-handed monozygotic (MZ) twins and 13 pairs of same-sex right-handed dizygotic (DZ) twins during a letter version of the verbal fluency task. Heritability was estimated based on a classical twin paradigm using structured equation modeling. Significant genetic influences were estimated in the right dorsolateral prefrontal cortex and left frontal pole. The degrees of heritability were 66% and 75% in the variances, respectively. This implies that the prefrontal hemodynamic dysfunction observed during an executive function task measured by NIRS may be an efficient endophenotype for large-scale imaging genetic studies in psychiatric disorders. (C) 2013 Elsevier Inc. All rights reserved.