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クワバラ ヒトシ
KUWABARA Hitoshi
桑原 斉 所属 埼玉医科大学 医学部 神経精神科・心療内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Genetic influences on prefrontal activation during a verbal fluency task in adults: A twin study based on multichannel near-infrared spectroscopy |
| 掲載誌名 | 正式名：NEUROIMAGE ISSNコード：10538119 |
| 出版社 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 巻・号・頁 | 85,508-517頁 |
| 著者・共著者 | Eisuke Sakakibara,Ryu Takizawa,Yukika Nishimura,Shingo Kawasaki,Yoshihiro Satomura,Akihide Kinoshita,Shinsuke Koike,Kohei Marumo,Masaru Kinou,Mamoru Tochigi,Nao Nishida,Katsushi Tokunaga,Satoshi Eguchi,Syudo Yamasaki,Tatsunobu Natsubori,Norichika Iwashiro,Hideyuki Inoue,Yosuke Takano,Kunio Takei,Motomu Suga,Hidenori Yamasue,Junko Matsubayashi,Kenji Kohata,Chie Shimojo,Shiho Okuhata,Toshiaki Kono,Hitoshi Kuwabara,Ayaka Ishii-Takahashi,Yuki Kawakubo,Kiyoto Kasai |
| 発行年月 | 2014/01 |
| 概要 | Near-infrared spectroscopy (NIRS) studies have reported that prefrontal hemodynamic dysfunction during executive function tasks may be a promising biomarker of psychiatric disorders, because its portability and noninvasiveness allow easy measurements in clinical settings. Here, we investigated the degree to which prefrontal NIRS signals are genetically determined. Using a 52-channel NIRS system, we monitored the oxy-hemoglobin (oxy-Hb) signal changes in 38 adult pairs of right-handed monozygotic (MZ) twins and 13 pairs of same-sex right-handed dizygotic (DZ) twins during a letter version of the verbal fluency task. Heritability was estimated based on a classical twin paradigm using structured equation modeling. Significant genetic influences were estimated in the right dorsolateral prefrontal cortex and left frontal pole. The degrees of heritability were 66% and 75% in the variances, respectively. This implies that the prefrontal hemodynamic dysfunction observed during an executive function task measured by NIRS may be an efficient endophenotype for large-scale imaging genetic studies in psychiatric disorders. (C) 2013 Elsevier Inc. All rights reserved. |
| DOI | 10.1016/j.neuroimage.2013.03.052 |
| PMID | 23558100 |