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カワサキ ヨウヘイ
KAWASAKI Yohei
川﨑 洋平 所属 埼玉医科大学 医学部 研究統括センター 職種 教授 |
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| 論文種別 | 学術雑誌(総説) |
| 言語種別 | 日本語 |
| 査読の有無 | 査読あり |
| 表題 | Modulation of Omega-6 Polyunsaturated Fatty Acid-dependent Signaling and its Therapeutic Potential for the Core Symptoms in Individuals with Autism Spectrum Disorders |
| 掲載誌名 | 正式名：Japanese Journal of Biological Psychiatry |
| 掲載区分 | 国外 |
| 出版社 | Japanese Society of Biological Psychiatry |
| 巻・号・頁 | 27(1),41-47頁 |
| 総ページ数 | 7 |
| 著者・共著者 | K. Yui, Y. Kawasaki, H. Yamada |
| 発行年月 | 2016 |
| 概要 | We examined the relationships between plasma levels of fatty acids and biomarkers of AA-related signaling mediators (ceruloplasmin, transferrin and superoxide dismutase) with the behavioral and social symptoms of 21 individuals with ASD (mean age, 13.1 ±, 4.5 years old) and 21 age-and gender-matched normal controls (mean age, 13.9 ±, 5.7 years old). Behavioral and social symptoms were assessed using the Aberrant Behavior Checklists (ABC) and Social Responsiveness Scale (SRS) respectively. To compensate reduced plasma AA levels, the 21 individuals with ASD were treated with supplementation (precursor of omega-6 PUFAS, linoleic acid 480 mg/day plus omega-3 PUFA precursor &alpha,-linoleinic acid 240mg/day) for 16 weeks. Plasma EPA levels and arachidic acid, and the plasma ratios of eicosapentaenoic acid (EPA) /AA and docosahesaenoic acid (DHA) /AA were significantly higher while plasma levels of AA and ceruloplasmin (Cp) were significantly lower in the 21 individuals with ASD c |
| DOI | 10.11249/jsbpjjpp.27.1_41 |