カワサキ　ヨウヘイ   KAWASAKI Yohei   川﨑　洋平    所属   埼玉医科大学  医学部 研究統括センター    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Practicality of STAT3 Gene Polymorphisms and Sorafenib Trough Concentration as Biomarkers for Sorafenib-Induced Hand-Foot Skin Reaction in Hepatocellular Carcinoma
掲載誌名	正式名：Journal of Clinical Pharmacy and Therapeutics
掲載区分	国外
出版社	Hindawi Limited
巻・号・頁	2023(1),6682459頁
総ページ数	9
著者・共著者	Hirokazu Takatsuka, Takato Sugawara, Masashi Uchida, Shingo Yamazaki, Takaaki Suzuki, Naoya Kanogawa, Sadahisa Ogasawara, Yuki Shiko, Yohei Kawasaki, Naoya Kato, Itsuko Ishii
発行年月	2023/08/19
概要	Introduction. The aim of this study was to evaluate the practicality of the signal transducer and activator of transcription (STAT) 3 polymorphisms as a predictive biomarker and sorafenib trough concentration as a monitoring biomarker for hand-foot skin reaction (HFSR) in patients with hepatocellular carcinoma (HCC). Methods. In total, 43 Japanese HCC patients were included. Sorafenib concentrations were measured, if possible, on days 8, 29, 35, and 57. The sorafenib concentration on day 8 (Cday8) was used for the analysis of HFSR occurring up to day 29. The median concentration for each patient (Cmedian) was used for HFSR occurring up to day 57 (study period). The STAT3 single nucleotide polymorphism (SNP) rs4796793 was determined using cell-free DNA extracted from plasma. Result. The Cday8 tended to be higher in the HFSR onset or grade ≥ 2 HFSR severity group than in the non-HFSR or grade ≤ 1 HFSR severity group. The Cmedian was significantly higher in the HFSR onset or grade ≥ 2 gro
DOI	10.1155/2023/6682459