ナガタ　コウセイ   NAGATA Kosei   永田　向生    所属   埼玉医科大学  医学部 総合医療センター　整形外科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.
掲載誌名	正式名：Nature communications 略　 称：Nat Commun ISSNコード：20411723/20411723
掲載区分	国外
巻・号・頁	13(1),6187頁
著者・共著者	Nagata Kosei, Hojo Hironori, Chang Song Ho, Okada Hiroyuki, Yano Fumiko, Chijimatsu Ryota, Omata Yasunori, Mori Daisuke, Makii Yuma, Kawata Manabu, Kaneko Taizo, Iwanaga Yasuhide, Nakamoto Hideki, Maenohara Yuji, Tachibana Naohiro, Ishikura Hisatoshi, Higuchi Junya, Taniguchi Yuki, Ohba Shinsuke, Chung Ung-Il, Tanaka Sakae, Saito Taku
発行年月	2022/10
概要	Here, we examined the role of Runx2 and Runx3 for osteoarthritis development in vivo and in vitro. Runx3-knockout mice exhibited accelerated osteoarthritis following surgical induction, accompanied by decreased expression of lubricin and aggrecan. Meanwhile, Runx2 conditional knockout mice showed biphasic phenotypes: heterozygous knockout inhibited osteoarthritis and decreased matrix metallopeptidase 13 (Mmp13) expression.
DOI	10.1038/s41467-022-33744-5
PMID	36261443