カワムラ　ヒデマサ   KAWAMURA Hidemasa   河村　英将    所属   埼玉医科大学  医学部 総合医療センター　放射線科(画像診断・核医学科、放射線腫瘍科)    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck in Gunma University
掲載誌名	正式名：Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology ISSNコード：2212-5558/2212-5566
出版社	Elsevier BV
巻・号・頁	34(3),280-286頁
著者・共著者	Atsushi Musha,Nobuteru Kubo,Naoko Okano,Takuya Kaminuma,Hidemasa Kawamura,Hiro Sato,Yukihiro Takayasu,Masato Shino,Osamu Nikkuni,Shota Ida,Katsuyuki Shirai,Jun-ichi Saitoh,Masaru Ogawa,Satoshi Yokoo,Kazuaki Chikamatsu,Tatsuya Ohno
発行年月	2021/11
概要	Objective: Data on the long-term outcomes of carbon-ion radiotherapy for non-squamous cell carcinomas are rare. Gunma University has been utilizing carbon-ion radiotherapy as a treatment for head and neck cancer since 2010. This study aimed to evaluate the long-term efficacy and safety of carbon-ion radiotherapy for the head and neck.Methods: We prospectively evaluated 35 patients with non-squamous cell carcinoma who underwent carbon-ion radiotherapy at Gunma University Heavy Ion Medical Center between 2010 and 2014. The 5-year local control, overall survival, and progression-free survival rates were evaluated. Results: The median age was 59 years (range, 31-77 years), and the median follow-up time was 65 months (range, 6.1-98.8 months). Overall, 32 and 3 patients received 64.0 Gy (relative biological effectiveness) and 57.6 Gy (relative biological effectiveness) in 16 fractions, respectively. Adenoid cystic carcinoma was the most dominant histopathological type (n = 21 patients, 60 %). The 5-year local control, progression-free survival, and overall survival rates were 74.5 %, 53.2 %, and 81.3 %, respectively. Nine patients had local recurrence, and six patients died. Adverse events included acute grade 3 radiation mucositis (Common Terminology Criteria for Adverse Events version 4.0) in 8 patients; this was improved immediately with conservative therapy. Late grade 4 adverse events were observed, including two cases of visual loss and one case of brain necrosis. No grade 5 adverse events were observed.Conclusion: Carbon-ion radiotherapy achieves excellent local control and overall survival rates in non-squamous cell carcinoma patients with expected adverse events. (C) 2021 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd.
DOI	10.1016/j.ajoms.2021.10.012