マツサカ　ヨウジ   MATSUSAKA Yohji   松坂　陽至    所属   埼玉医科大学  医学部 国際医療センター　放射線科（放射線腫瘍科、画像診断、核医学科）    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	3D SPECT/CT fusion using image data projection of bone SPECT onto 3D volume-rendered CT images: feasibility and clinical impact in the diagnosis of bone metastasis
掲載誌名	正式名：ANNALS OF NUCLEAR MEDICINE ISSNコード：09147187
出版社	SPRINGER
巻・号・頁	31(4),304-314頁
著者・共著者	Yuji Ogata,Tadaki Nakahara,Kenichi Ode,Yohji Matsusaka,Mari Katagiri,Yu Iwabuchi,Kazunari Itoh,Akira Ichimura,Masahiro Jinzaki
発行年月	2017/05
概要	Purpose We developed a method of image data projection of bone SPECT into 3D volume-rendered CT images for 3D SPECT/CT fusion. The aims of our study were to evaluate its feasibility and clinical usefulness.Methods Whole-body bone scintigraphy (WB) and SPECT/CT scans were performed in 318 cancer patients using a dedicated SPECT/CT systems. Volume data of bone SPECT and CT were fused to obtain 2D SPECT/CT images. To generate our 3D SPECT/CT images, colored voxel data of bone SPECT were projected onto the corresponding location of the volume-rendered CT data after a semi-automatic bone extraction. Then, the resultant 3D images were blended with conventional volume-rendered CT images, allowing to grasp the three-dimensional relationship between bone metabolism and anatomy. WB and SPECT (WB + SPECT), 2D SPECT/CT fusion, and 3D SPECT/CT fusion were evaluated by two independent reviewers in the diagnosis of bone metastasis. The inter-observer variability and diagnostic accuracy in these three image sets were investigated using a four-point diagnostic scale.Results Increased bone metabolism was found in 744 metastatic sites and 1002 benign changes. On a per-lesion basis, inter-observer a
DOI	10.1007/s12149-017-1158-3
PMID	28243844