ババ　ヤスタカ   BABA Yasutaka   馬場　康貴    所属   埼玉医科大学  医学部 国際医療センター　放射線科（放射線腫瘍科、画像診断、核医学科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Green tea catechin, epigallocatechin-3-gallate, attenuates the cell viability of human non-small-cell lung cancer A549 cells via reducing Bcl-xL expression
掲載誌名	正式名：EXPERIMENTAL AND THERAPEUTIC MEDICINE ISSNコード：17920981
出版社	SPANDIDOS PUBL LTD
巻・号・頁	8(1),59-63頁
著者・共著者	Jun-Ichiro Sonoda,Ryuji Ikeda,Yasutaka Baba,Keiko Narumi,Akio Kawachi,Erisa Tomishige,Kazuya Nishihara,Yasuo Takeda,Katsushi Yamada,Keizo Sato,Toshiro Motoya
発行年月	2014/07
概要	Clinical and epidemiological studies have indicated that the consumption of green tea has a number of beneficial effects on health. Epigallocatechin-3-gallate (EGCg), the major polyphenolic compound present in green tea, has received much attention as an active ingredient. Among the numerous promising profiles of EGCg, the present study focused on the anticancer effects. Apoptosis induced by EGCg and subsequent cell growth suppression have been demonstrated in a number of cell culture studies. However, the underlying mechanism of apoptotic cell death remains unclear. Thus, the aim of the present study was to identify the major molecule that mediates proapoptotic cell death by EGCg. The effect of EGCg on cell proliferation and the induction of mRNA that modulates apoptotic cell death was evaluated in the A549 human non-small-cell lung cancer cell line. In addition, morphological changes were assessed by microscopy in A549 cells that had been treated with 100 mu M EGCg for 24 h. The MTT assay revealed that cell proliferation was significantly reduced by EGCg in a dose-dependent manner (3-100 mu M). The mRNA expression level of B-cell lymphoma-extra large (Bcl-xL) was decreased in A54
DOI	10.3892/etm.2014.1719