ババ　ヤスタカ   BABA Yasutaka   馬場　康貴    所属   埼玉医科大学  医学部 国際医療センター　放射線科（放射線腫瘍科、画像診断、核医学科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Reduction of oxidative stress in liver cancer patients by oral green tea polyphenol tablets during hepatic arterial infusion chemotherapy
掲載誌名	正式名：EXPERIMENTAL AND THERAPEUTIC MEDICINE ISSNコード：17920981
出版社	SPANDIDOS PUBL LTD
巻・号・頁	4(3),452-458頁
著者・共著者	Yasutaka Baba,Jun-Ichiro Sonoda,Sadao Hayashi,Shunro Sonoda,Kanro Makisumi,Masayuki Nakajo
発行年月	2012/09
概要	Hepatic arterial infusion chemotherapy (HA I) using an implanted port system is the standard regimen for primary and metastatic liver cancers (MLCs). However, there have been few studies concerning HAI-induced oxidative stress and damage to the liver or other organs. The aim of the present study was to investigate the ability of green tea polyphenols (GTPs) to reduce the oxidative stress or increase the biological antioxidative potential in HAI-treated patients. A total of 19 patients with inoperable hepatocellular carcinoma (HCC) or MLC from colorectal malignancy were eligible for HAI with cisplatin (CDDP) and 5-fluorouracil (5FU). The study subjects were randomly assigned to either a 3 or a 6 oral GTP tablets per day group. Each tablet had a GTP content equivalent to 79 mg of epigallocatechin-3-gallate. The oxidative stress was assessed by measuring the levels of derivatives of reactive oxygen metabolites (d-ROMs) and the biological antioxidative potential (BAP) values in patient plasma using the Free Radical Analytical System 4 (FRAS4), and correlating the results with clinical laboratory data for the patients. The levels of d-ROMs were significantly reduced by the oral intake o
DOI	10.3892/etm.2012.602