ヤマダ　タケト   YAMADA Taketo   山田　健人    所属   埼玉医科大学  医学部 病理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Islet number rather than islet size is a major determinant of beta and alpha cell mass in humans
掲載誌名	正式名：Journal of Clinical Endocrinology & Metabolism
巻・号・頁	99(5),1733-1740頁
著者・共著者	Kou K, Saisho Y, Sato S, Yamada T, Itoh H
発行年月	2014/02
概要	The objective of the study was to clarify the relative contribution of islet number and islet size to β- and α-cell mass in humans. There was considerable interindividual variation in islet density and mean islet size, with a significant negative correlation between the two. There were significant positive correlations between islet density and %BCA or %ACA, whereas mean islet size correlated with neither of them. Islet density as well as %BCA, but not mean islet size, was negatively correlated with glycosylated hemoglobin. The present study suggests that islet number rather than islet size is a major determinant of β- and α-cell mass in humans. Interindividual difference in islet number may contribute to susceptibility to development of glucose intolerance.